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Research topics
Humans and other animals need to
perceive and react to sensory
signals to survive and flourish in
their environment. The perception of
sensory signals, in turn, is highly
dynamic and strongly shaped by
physiological and bodily states
including the level of arousal,
motor movements and attention. The
overarching goal of our research
group is to decipher the precise
mechanisms in the brain by which
physiological and bodily states
shape our perception and how
disruptions in these mechanisms
contribute to the etiology of
psychiatric disorders.
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Scientific Approach
For our research, we make use of in
vivo intracellular and extracellular
high-density neural recordings,
mouse behavior, and optogenetics.
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Related Publications
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Nestvogel D.B., McCormick DA.,
Visual Thalamocortical
Mechanisms of Waking
State-Dependent Activity and
Alpha Oscillations (2022).
Neuron 110, 120-138.e4
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McCormick, D. A., Nestvogel, D.
B., & He, B. J. (2020).
Neuromodulation of Brain State
and Behavior. Annual Review of
Neuroscience.
https://doi.org/10.1146/annurev-neuro-100219-105424
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Nestvogel, D.B., Merino, R.M.,
Leon-Pinzon, C., Schottdorf, M.,
Lee, C., Imig, C., Brose, N.,
and Rhee, J.-S. (2020). The
Synaptic Vesicle Priming Protein
CAPS-1 Shapes the Adaptation of
Sensory Evoked Responses in
Mouse Visual Cortex. Cell
Reports 30, 3261–3269.e4.
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Neske, G.T., Nestvogel, D.,
Steffan, P.J., and McCormick,
D.A. (2019). Distinct Waking
States for Strong Evoked
Responses in Primary Visual
Cortex and Optimal Visual
Detection Performance. Journal
of Neuroscience 39, 10044–10059.
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