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Principal Investigator
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Address
Ludwig-Maximilians-Universität München
Department Biology II
Grosshadernerstr. 2
82152 Planegg-Martinsried
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Phone
+49-89-2180-74305
Email
busse@bio.lmu.de
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Research topics
Context has powerful influences on perception and on the neural activity in sensory areas. Information processing occurs through the concerted action of specific cell types in neuronal assemblies to guide sensation and behavior. We investigate the influence of context on sensory representations in the visual system at the level of the neuronal circuit. How do specific cells and circuits relate to visual processing, and how they drive behaviour?
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Scientific approach
To monitor activity in local populations of the neuronal circuit we use multi-channel extracellular recordings in awake behaving mice. In several projects, we train mice to perform highly controlled visual tasks. We combine these neural recordings with causal manipulations of circuit elements using genetic tools, such as optogenetics.
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Related Publications
- Khastkhodaei, Z., Jurjut, O., Katzner, S., and Busse, L. (2016). Mice can use second-order, contrast-modulated stimuli to guide visual perception. J Neurosci, 36(16):4457–69.
- Erisken, S., Vaiceliunaite, A., Jurjut, O., Fiorini, M., Katzner, S., and Busse, L. (2014). Effects of locomotion extend throughout the mouse early visual system. Current Biology, 24(24):2899– 2907.
- Vaiceliunaite, A., Erisken, S., Franzen, F., Katzner, S., and Busse, L. (2013). Spatial integration in mouse primary visual cortex. Journal of Neurophysiology, 110(4):964–972.
- Busse, L., Ayaz, A., Dhruv, N. T., Katzner, S., Saleem, A. B., Schölvinck, M. L., Zaharia, A. D., and Carandini, M. (2011). The detection of visual contrast in the behaving mouse. The Journal of Neuroscience, 31(31):11351–11361.
- Busse, L., Wade, A. R., and Carandini, M. (2009). Representation of concurrent stimuli by population activity in visual cortex. Neuron, 64(6):931–942.
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